Indonesian Journal of Tropical and Infectious Disease
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination.
The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
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<![CDATA[Natural Growth Factor: Platelet Rich Plasma Stimulates Proliferation of Fibroblast Cell Culture ]]>
<![CDATA[Ernie Maduratna Setiawati]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2177
<![CDATA[Platelet rich plasma(PRP) is a source of many natural growth factor that can modulate wound healing. PRP has become a valuable adjunct in dentistry. Fibroblast cell in ligament periodontal play on important role in periodontal regeneration. The study was performed to investigate the influence PRP 10%–100% on the proliferation of fibroblast cell culture in vitro. A fibroblast culture was estabilished from baby hamster kidney (BHK-21) were tested on proliferation was measured with MTT assay after induced PRP 10–100%. We showed that PRP stimulate the proliferation of fibroblast, PRP 80% as the optimal choice to a good enough proliferative stimulus. PRP has proven to be effective at improving surgical results in periodontal surgery. PRP also show promise in periodontal regenerative medicine.]]>
<![CDATA[Identification of Streptomyces sp-MWS1 Producing Antibacterial Compounds ]]>
<![CDATA[Wiwin retnowati]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2171
<![CDATA[An actinomycete, designated Streptomyces sp-MWS1, was isolated from mangrove ecosystem soil in the eastern coast of Surabaya. This organism was capable of producing a series of antibiotics that strongly inhibit the growth of Gram-positive and Gram-negative bacteria. Furthermore, culture morphological and physiological characteristics of the isolated strain, Streptomyces sp-MWS1 were compared to other reference strains belong to Streptomyces species. The analysis of nucleotide sequence of the 16S rDNA indicated similarity binary 98% with Streptomyces species.]]>
<![CDATA[Serotype and Clinical Performance of Dengue Virus Infection on the Year 2009 ]]>
<![CDATA[Soegeng Soegijanto]]>;
<![CDATA[Widodo Darmowandowo]]>;
<![CDATA[Amor Peraten Ginting]]>;
<![CDATA[Atsushi Yamanaka]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2161
<![CDATA[Dengue hemorrhagic fever is one of the important health problem in Indonesia, mortality rate is becoming decrease but many dengue shock syndrome cases is very difficult to be help. Previous study showed that some of DEN 2 and DEN 3 virus cases could show a clinical performance of severe dengue virus infection such as dengue shock syndrome. There are four serotype of dengue virus infection can cause primary and secondary infection. The aim of this research is to know the relationship between clinical performance of dengue virus infection and serotype dengue virus and also to know the role of primary and secondary infection and age of dengue virus cases. A prospective analytic observational study, which was conducted in Dr. Soetomo hospital since January 2009. RT-PCR was used to attempt to identify the infecting serotype from dengue virus isolated using vero cell. Antibody responses were measured by ELISA and clinical manifestation were measured with the WHO criteria 1997. Dengue serotype identification by RT-PCR was 70 patients. Virus types were DEN-2 65(92.8%), DEN-1 3(4.2%), and DEN-3 2(2.8%). Patients with DEN-1 genotype IV were more trend severe disease DSS and unusual infection. Commanly usually secondary exposure cause more severe clinical manifestation than primary exposure (p = 0.035) but in this study found that all of DEN-1 genotype IV, primary or secondary infection to show severe clinical manifestation of dengue virus infection. We can conclude that DEN-2 was the most dominant serotype in Dr. Soetomo Hospital. On Primary and secondary infection, DEN-1 genotype IV showing more severe than DEN-2 and DEN-3.]]>
<![CDATA[Neonatal Sepsis in Low Birth Weight Infants in Dr. Soetomo General Hospital ]]>
<![CDATA[Martono Tri Utomo]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2172
<![CDATA[Infections of the newborn are a significant cause of mortality. Preterm infant have a high risk sepsis.. The incidence of neonatal sepsis is 1 to 10 cases per 1000 live births and 1 per 250 live premature births. To describe the characteristics of neonatal sepsis in the low birth weight infant in the neonatal intensive care unit Dr. Soetomo Hospital. Retrospective analysis. The data were collected from the medical record of low birth weight infants who were diagnosed as sepsis in neonatal care unit of Dr. Soetomo Hospital between January 2010 to June 2010 with purposive sampling. Descriptive analysis of risk factor of sepsis and blood culture of the patient was calculated. Chi-square analysis was performed in the laboratorium data. Characteristics sample: male vs female 61% vs 39%, outcome of sepsis in LBW was death 69%, alive 25%, risk of infection: turbid amniotic fluid 21%, asphyxia 33%. Laboratorium data leucopenia and thrombocytopenia (P < 0.05). Blood culture: Klebsiella pnemoniae. The incidence and mortality of neonatal sepsis in LBW infants was still high. Asphyxia, turbid amniotic fluid, leucopenia and thrombocytopenia were associated with sepsis. pneumoniae was the most common organisms in the LBW sepsis infants.]]>
<![CDATA[The Fluctuation of Aedes Aegypti in Endemic Area of Dengue Hemorrhagic Fever in Surabaya City, Indonesia ]]>
<![CDATA[Subagyo Yotopranoto]]>;
<![CDATA[Kusmartisnawati Kusmartisnawati]]>;
<![CDATA[Kris Cahyo Mulyatno]]>;
<![CDATA[Heny Arwati]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2163
<![CDATA[This research was aimed to describe the density pattern and the fluctuation of Aedes aegypti larval based on the season in dengue haemorrhagic fever (DHF) endemic area in Surabaya city. The population of the research was the house of people together with its breeding sites either inside and outside the house. The 55 houses were randomly chosen in 11 RWs in Nginden Subdistrict. The sample of this research was Aedes aegypti larva obtained from its breeding sites. The sample sizes were all of the larval in the containers existed in the chosen houses. The samples of the larval were taken and carried for identification and documentation of the species. This research was applied in the same houses in January, March, and May 2008 in rainy season. The results indicated that the highest larval index occurred in January with House Index (HI) 76.8%, Container Index (CI) 40.5%, and Breteau Index (BI) 137.5%. There was a decrease in March with HI 63.3%, CI 31.3%, and BI 92.7%. It continued to decrease in May with HI 42.6%, CI 21.1%, and BI 57.4%. All of those larval indices in the three observed months showed a high percentage of larval which was much higher than the safe limit or the critical threshold (5%) as defined by WHO. It implied that people in Nginden Subdistrict were threaten by the infection of DHF. The three indices achieved the peak in January, which was also the peak of the rainy season. It gradually decreased in March and May as the rainy season decreased its intensity of rain. Larval Density Index (LDI) also showed a high value. There were 173 larval/house in January, 187 larval/house in March, and 84.8 larval/house in May. The containers or breeding sites of Aedes were mostly found in January then their existences gradually decreased in March and May. Traditional bath tub was the most productive container inside the house, while drum and bucket were the most productive containers outside the house. Other containers which contributed abundance of larval were refrigerator, flower pot, well, and PDAM meter box.]]>
<![CDATA[Antibiotic Resistance Control Program in Pediatric Hematology and Oncology Patients at Dr. Soetomo Hospital in 2006–2007 ]]>
<![CDATA[Mia Ratwita Andarsini]]>;
<![CDATA[I Dewa Gede Ugrasena]]>;
<![CDATA[Bambang Permono]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2173
<![CDATA[Antibiotic resistance has been increasing since the first years of the clinical usage. It caused by inappropriate usage and uncontrol of antibiotic drugs. Therfore an Antibiotic Resistance Control Program (ARCP) is needed to overcome the problem. The purpose of this study is to know microorganism pattern and evaluate antibiotic use. Phase 1 (before ARCP), retrospective study by medical record of pediatric hematology-oncology patients with suspision of infection and admitted at dr Soetomo Hospital from June–August 2006 was carried out. Phase 2 (during ARCP), a prospective observational study was done from November 2006 to January 2007. We were evaluated the isolated microorganism, quantity of antibiotic were determined by Defined Daily Doses (DDD)/100 patients-days, quality of antibiotics usage were assessed with Glyssen classification, and the cost calculation of antibiotic therapy. Twenty seven patients were enrolled in phase 1 and 28 patients in phase 2. Coagulase-negative Staphylococci and Acinetobacter Sp as isolated microorganism was reported. Phase 1, the most sensitive antibiotic was Cefoperazone-Sulbactam and the most resistant was Penicillin G. Phase 2, Meropenem was the most sensitive antibiotic and Cotrimoxazole was the most resistant antibiotic. The use of antibiotics were decreased 6 vs 12 and DDD/100 patients-days were 14.52 vs 45.04. There were improving of Glyssen classification. The cost calculation of antibiotics therapy were decreased. ARCP can improve antibiotic use in pediatric hematology-oncology patients.]]>
<![CDATA[Mycobacterium leprae in Daily Water Resources of Inhabitants Who Live in Leprosy Endemic Area of East Java ]]>
<![CDATA[Ratna Wahyuni]]>;
<![CDATA[Dinar Adriaty]]>;
<![CDATA[iswahyudi iswahyudi]]>;
<![CDATA[Cita Rosita S. Prakoeswa]]>;
<![CDATA[Indropo Agusni]]>;
<![CDATA[shinzo izumi]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2164
<![CDATA[Leprosy still a health problem in Indonesia, where many leprosy pocket areas still persists, especially in the eastern part of the country. Although the program of WHO – Multidrug Therapy (MDT) regiment has been conducted elsewhere since 1980s, only the prevalence can be reduced but not the incidence of new leprosy cases. Theoretically after the source of leprosy (the infectious leprosy cases) has been treated, no more transmission of the disease and should be no more new leprosy cases will be found. To explain this phenomenon, the non-human resource of M.leprae became a new topic of debates, especially the existence of bacteria in the environment. A field study of the existence of M.leprae in the environment of leprosy endemic area had been conducted in a leprosy endemic area of the northern part of East Java. The aim of the study is to find any correlation of the existence of these bacteria in the environment with the presence of leprosy patients who live in that area, in order to study its role in the transmission of the disease. Ninety water samples from wells in the house of inhabitants who live in one endemic sub district were collected. The owner of the well was interviewed whether any leprosy patients who routinely use the water for their daily life activities. Water samples were examined by Polymerase Chain Reaction (PCR) method to detect M.leprae DNA, using the LpF-LpR and Lp3-Lp4 nested primers (99bp). The PCR results showed positive band for M.leprae in 22 out of 90 (24%) water samples. Water samples from wells that used by leprosy patients showed positive PCR in 11/48 (23%), while 11 out of 42 (26%) water samples from wells that never been used by leprosy cases showed positive result. Statistically there was no difference (p>0.05) in the positivity of M.leprae between the two groups. It was concluded that the existence of M.leprae in the daily water resource was not correlated with the present of leprosy cases in the area. Possible symbiosis between protozoan and mycobacterium in the environment were discussed.]]>
<![CDATA[Description Analysis of Human Behavior that Causes the Emergence of HIV/AIDS Infectious Diseases in Surabaya ]]>
<![CDATA[Yayuk Susilawati]]>;
<![CDATA[Nasronudin Nasronudin]]>;
<![CDATA[atika atika]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2174
<![CDATA[HIV virus is transmitted to other individuals particularly through sexual contact with infected individuals, narcotic abuse using shared infected needle, maternal-fetal transmission in perinatal period, either during pregnancy, labor, and breastfeeding, or through infected blood donor. The diagnosis of HIV/AIDS infection is established using laboratory examination with the indication of clinical symptoms or high risk behavior. This descriptive study was intended to describe human behaviors that cause the occurrence of HIV/AIDS in Surabaya. To find the description of the disease, the percentage of total HIV/AIDS patients according to behavioral risk factors was estimated. Total patients in 9 hospitals at each risk factor were divided with total patients in those hospital, multiplied with 100. The description of the disease according to behavioral risk factors in Surabaya is as follows: total patients between January and December 2005 was 382 individuals; 204 due to sexual contact (53.40%), 161 due to injected drug use (IDU) (42.15%), 6 perinatal cases (1.57%) and 11 with unknown causes (2.88%). From risk factor sexual relationship behavior as many as 204 people, respectively heterosexual 174 people (85.29%), homosexual 17 people (8.33%) and bisexual 13 people (6.37%). Further analytical studies are needed to analyze correlation between human behavior and the occurrence of HIV/AIDS in Surabaya.]]>
<![CDATA[A Patient with Suspected Diphtheria ]]>
<![CDATA[Muhammad Vitanata Arfijanto]]>;
<![CDATA[Siti Irma Mashitah]]>;
<![CDATA[Prihartini Widiyanti]]>;
<![CDATA[Bramantono Bramantono]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2169
<![CDATA[It was reported that a mature woman, Mrs. S, 42 years old with several complaints and symptoms such as fever, swallowing painweak body, swollen tonsil with beslag, dirty uvula of mouth cavity and tongue, and bullneck. The final diagnosis indicated that thepatient was suspected diphtheria, candidiasis oris, sepsis, and pneumonia. The sudden death of the patient was probably caused bymyocarditis.]]>
<![CDATA[Tropical Disease Prevention and Control: Is It Now Knowledge Management Era? ]]>
<![CDATA[Adithya Sudiarno]]>;
<![CDATA[Arief Rahman]]>;
<![CDATA[Sri Gunani Partiwi]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010) ]]>
Publisher : <![CDATA[Institute of Topical Disease Universitas Airlangga ]]>
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DOI: 10.20473/ijtid.v1i2.2176
<![CDATA[Indonesia is the part of developing Asian countries, until now still not declared free from various types of tropical diseases. Whereas, several years ago Indonesia has declared free from various kinds of tropical diseases, but in fact, tropical diseases up to now still cannot be eliminated. Moreover the prevalence rates of tropical diseases tended to increase from year to year. One of the reasons Indonesia is a tropical climate, but in fact we are not able to control the climate. In this condition, what we can do is to raise public awareness so the spread of the disease can be controlled. It was time for an early awareness efforts conducted in a participatory manner by all stakeholders. In this case, stakeholders can be health practitioners, researchers, policy makers (official), and even the citizens. Participatory awareness can be enhanced if we have an integrated system that can accommodate all knowledge about tropical disease. The knowledge consists of characteristic about disease, potential risk, how to cure, how to isolate disease in community, and absolutely important is how to prevent of illness, etc. This paper aims to propose an integrated system called Tropical Disease Knowledge Management System (TDKMS) for enhancing the participatory awareness.]]>
